Prospective evaluation of a large language model clinical decision support system in the emergency department
Hoot, N. R. & Aronsky, D. Systematic review of emergency department crowding: causes, effects, and solutions. Ann. Emerg.…
The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis
Ethical approvals This research complies with all relevant ethical regulations. Animal studies carried out in Leeds were regulated…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Divergent impacts of explainable AI for dermatological diagnosis on clinicians versus lay people
Study design We designed two complementary large-scale experiments to evaluate human−AI collaborative diagnostic performance across expertise levels (Fig.…
Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial
Trial design and oversight The STIMULATE-ICP trial aimed to investigate the efficacy of an enhanced ICP for LC,…
Genomas Brasil program: building precision public health within Brazil’s Unified Health System
Patel, H. N. et al. J. Pharm. Bioallied Sci. 17, S1101–S3 (2025). Article PubMed PubMed Central Google Scholar …
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
Evaluating the robustness and readiness of large frontier models in health AI applications
Singhal, K. et al. Large language models encode clinical knowledge. Nature 620, 172–180 (2023). Article CAS PubMed PubMed…
General-purpose chatbots outperform clinical AI tools on physicians’ real-world questions
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This…
Medically tailored meals receipt and healthcare utilization and costs in Massachusetts’ Medicaid demonstration
Study design and setting We used a propensity score weighted, difference-in-difference analysis of adult MassHealth members with one…
Enabling secure discovery in trusted research environments with improved tooling
Competing interests V.J.S. was previously a research scholar for OFH. M.C.M. is a research ambassador for OFH, is…