Entering the era of precision medicine to treat amyotrophic lateral sclerosis | Molecular Neurodegeneration
Goutman SA, Hardiman O, Al-Chalabi A, Chió A, Savelieff MG, Kiernan MC, Feldman EL. Emerging insights into the…
Speech digital biomarker combined with fluid biomarkers predict cognitive impairment through machine learning | Alzheimer’s Research & Therapy
Demographics, clinical characteristics, core AD fluid, digital and imaging biomarkers among groups A total of 1223 participants were…
Genetic testing of common and rare variants in dementia patients from a memory clinic | Alzheimer’s Research & Therapy
2023 Alzheimer’s disease facts and figures. Alzheimers Dement 19, 1598–1695 (2023). Campion D, et al. Early-onset autosomal dominant…
Brain somatic mutations in Alzheimer’s disease: linking genetic mosaicism to neurodegeneration | Molecular Neurodegeneration
Zhang XX, Tian Y, Wang ZT, Ma YH, Tan L, Yu JT. The epidemiology of alzheimer’s disease modifiable…
Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease | Journal of Neuroinflammation
Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15(9):545–58. CAS PubMed Google Scholar …
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity | Journal of Neuroinflammation
In this study, we analysed HP‒EC tissue from 8 AD patients (mean age: 86.5 years, 5 males, 3…
A genetic common factor underlying self-reported math ability and highest math class taken
Spearman C. The Abilities of Man: Their Nature and Measurement. New York: Macmillan; 1927. Google Scholar Jensen AR.…
Positive association between Internet use and mental health among adults aged ≥50 years in 23 countries
Global Health Data Exchange (GHDx) (Institute of Health Metrics and Evaluation, accessed 1 November 2023); https://vizhub.healthdata.org/gbd-results Mental Health…
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions
Study design and data sources The data used in this study are collected and used in line with…
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program
Enrollment rates Between 28 September 2023 and 10 June 2024 (~8.5 months), a total of 2,125 newborns were enrolled.…
Genetic and molecular landscape of comorbidities in people living with HIV
Participants from the 2000HIV study The 2000HIV study is a prospective multicentric observational longitudinal cohort of virally suppressed…
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function
Ethics statement This study included de-identified data from participants who had consented to the use of their anonymized…