US Department of Health and Human Services, Food and Drug Administration & Center for Drug Evaluation and Research (CDER). Obesity and overweight: developing drugs and biological products for weight reduction guidance for industry. FDA https://www.fda.gov/media/71252/download (2025).

Tinsley, G. M. & Heymsfield, S. B. Fundamental body composition principles provide context for fat-free and skeletal muscle loss with GLP-1 RA treatments. J. Endocr. Soc. 8, bvae164 (2024).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Langer, H. T. et al. Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans. Cell Rep. Med. 7, 102665 (2026).

Article 
PubMed 
PubMed Central 

Google Scholar
 

Heymsfield, S. B. et al. Bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trial. Nat. Med. 32, 869–882 (2026).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Kochlik, B. et al. Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients. J. Cachexia Sarcopenia Muscle 14, 157–166 (2023).

Article 
PubMed 

Google Scholar
 

Crow, R. S. et al. Reported weight change in older adults and presence of frailty. J. Frailty Aging 9, 74–81 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Winter, J. E., MacInnis, R. J., Wattanapenpaiboon, N. & Nowson, C. A. BMI and all-cause mortality in older adults: a meta-analysis. Am. J. Clin. Nutr. 99, 875–890 (2014).

Article 
CAS 
PubMed 

Google Scholar
 

Prokopidis, K. Glucagon-like peptide-1 receptor agonists and muscle strength changes in older adults: risks beyond muscle mass reductions. Br. J. Pharmacol. https://doi.org/10.1111/bph.70355 (2026).

Article 
PubMed 

Google Scholar
 

Suetta, C. et al. Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle. J. Physiol. 591, 3789–3804 (2013).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar
 

Goodpaster, B. H. et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J. Gerontol. A Biol. Sci. Med. Sci. 61, 1059–1064 (2006).

Article 
PubMed 

Google Scholar
 

West, S. et al. Weight regain after cessation of medication for weight management: systematic review and meta-analysis. BMJ 392, e085304 (2026).

Article 
PubMed 
PubMed Central 

Google Scholar
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