Human tau pathology is associated with lonely, nontraveling slow waves linked to memory impairment
Rönnlund, M., Nyberg, L., Bäckman, L. & Nilsson, L.-G. Stability, growth, and decline in adult life span development…
Probing the proteome at cellular scale
When a fertilized mammalian egg divides, it yields two seemingly identical daughter cells. Some of their descendants generate…
Representations of the intrinsic value of information in mouse orbitofrontal cortex
Subjects All experimental and surgical protocols were performed in accordance with the guide of Care and Use of…
Chromatix: a differentiable, GPU-accelerated wave-optics library
Design and implementation The design of Chromatix is strongly inspired by current deep learning frameworks. Here we detail…
Why a synthetic human genome is still worth building
Ten years ago, when I was a first-year graduate student, my PhD adviser smuggled me into a private…
Genetic survey exposes flaws in widely used mouse models
C57BL/6 mice, such as the one pictured here, are commonly used in animal research. Credit: Dani Maver/Alamy Half…
How do genetic association studies rank genes?
RESEARCH BRIEFINGS 19 November 2025 Genome-wide association studies and rare-variant burden tests are the two main tools for…
MSnLib: efficient generation of open multi-stage fragmentation mass spectral libraries
Materials All solvents used were of LC–MS grade. Methanol, acetonitrile, water and formic acid were obtained from Thermo…
The unexpected value of communicating science to the public
Rust, N. C. Our memory is even better than experts thought. Sci. Am. https://www.scientificamerican.com/article/our-memory-is-even-better-than-experts-thought/ (2021). Sutton, R. S.…
Morphological map of under- and overexpression of genes in human cells
Mattiazzi Usaj, M. et al. High-content screening for quantitative cell biology. Trends Cell Biol. 26, 598–611 (2016). CAS …
The Platinum Pedigree: a long-read benchmark for genetic variants
Gonzaga-Jauregui, C., Lupski, J. R. & Gibbs, R. A. Human genome sequencing in health and disease. Annu. Rev.…
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines
The success of large language models in knowledge representation has spawned efforts to apply the foundation model concept…