Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health
Ethics Our research complies with all relevant ethical regulations. All studies included in this research were approved by…
Nucleotide dependency analysis of genomic language models detects functional elements
SpeciesLM training For SpeciesLM metazoa, we obtained metazoan genomes comprising 494 different species from the Ensembl 110 database36.…
Tip Sheet: Expert insights into full-body MRIs and multi-cancer detection tests, breastmilk antibodies — and progress in AI for cancer research
SEATTLE — Oct. 7, 2025 — Below are summaries of recent Fred Hutch Cancer Center research findings, patient…
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq
Constructing the scTF-seq library and single-cell atlas To establish scTF-seq, we built a dox-inducible lentiviral open reading frame…
A genetic map of human metabolism across the allele frequency spectrum
Study design The UKB is a prospective cohort study from the UK that contains more than 500,000 volunteers…
Study says COVID vaccine linked to six forms of cancer |
Image credits: Getty Images When it comes to the US, people have already been skeptical of getting vaccinated…
Limited overlap between genetic effects on disease susceptibility and disease survival
Ethics statement This study was conducted in compliance with the relevant ethical guidelines and approved by the appropriate…
A clinical milestone for CRISPR in sickle-cell disease
The haemoglobinopathies transfusion-dependent β-thalassemia (TDT) and sickle-cell disease (SCD) are two globally prevalent and severe monogenic blood disorders.…
This Badass Creature Has the Power to Kill Brain Tumors—and Scientists Found a Way to Use It
Time and again, the adrenaline-inducing show Fear Factor brought out scorpions to scare contestants. As the arachnids crept…
Advances in haplotype phasing and genotype imputation
Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in…
Rapid epigenomic classification of acute leukemia
A comprehensive DNA methylation reference of acute leukemia We curated a comprehensive DNA methylation-based reference cohort from published…
A genomic view of Earth’s biomes
Giovannoni, S., Britschgi, T., Moyer, C. & Field, K. Genetic diversity in Sargasso sea bacterioplankton. Nature 345, 60–63…