Tracing the evolution of single-cell 3D genomes in Kras-driven cancers
Ethics Statement All animal studies were approved by the Institutional Animal Care and Use Committee of Yale University.…
Graves Gilbert Clinic discusses advancements in breast cancer research for Breast Cancer Research Day
BOWLING GREEN, Ky. – Today is World Breast Cancer Research Day, and across the country, thousands of women…
Large-scale genome-wide analyses of stuttering
Yairi, E. & Ambrose, N. Epidemiology of stuttering: 21st century advances. J. Fluen. Disord. 38, 66–87 (2013). Google…
From gene hunter to drug hunter
Howard Chang wasn’t looking for a change from his job at Stanford, where he worked as both a…
A Society-to-Cells approach to evaluating multilevel and interrelated drivers of breast cancer disparities in Black women
Miller, K. D. et al. Cancer treatment and survivorship statistics, 2019. CA Cancer J. Clin. 69, 363–385 (2019).…
LDAK-KVIK performs fast and powerful mixed-model association analysis of quantitative and binary phenotypes
Uffelmann, E. et al. Genome-wide association studies. Nat. Rev. Methods Prim. 1, 59 (2021). CAS Google Scholar Visscher,…
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states
Regev, A. et al. The human cell atlas. eLife 6, e27041 (2017). PubMed PubMed Central Google Scholar Karlsson,…
Strengthening Africa’s brain health and economic resilience
United Nations Department of Economic and Social Affairs, Population Division. World Population Prospects 2024: Online Edition (United Nations,…
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
GBD Chronic Kidney Disease Collaboration Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis…
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
Fogg, C. et al. The dynamics of frailty development and progression in older adults in primary care in…
Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice
GWAS identifies SBRR1 tightly associated with ShB resistance To investigate resistance to R. solani in rice, we evaluated…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). Google Scholar GarcÃa-GarcÃa,…