Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Adapting prime editing for mammalian histone mutagenesis Mouse canonical histone H3 is encoded by nine H3.1 and three…
A Single Infusion Could Suppress H.I.V. for Years, Study Suggests
For about a decade, scientists have had remarkable success curing some blood cancers by modifying a patient’s own…
A.I. Bots Told Scientists How to Make Biological Weapons
One evening last summer, Dr. David Relman went cold at his laptop as an A.I. chatbot told him…
Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport
Cell culture Cells were grown in complete DMEM medium (D5796, containing 4,500 mg l−1 glucose, 2 mM L-glutamine) supplemented with dialysed…
Ligand-specific activation trajectories dictate GPCR signalling in cells
Biosensor constructionGibson assembly All cloning, except for site-directed mutagenesis, was conducted using Gibson assembly (NEBuilder HiFi DNA Assembly…
China Biotech Scientists Push Boundaries in Animal Testing
The pig was only a few months old when its legs began to buckle. At first, the animal…
After 1- and 6-Month Gains, Gene Editing Companies Await Q3 Results
As developers of gene editing therapies and other genetic medicines get set to report third quarter earnings in…
APHIS Deregulates Corn Developed Using Genetic Engineering to Resist Certain Pests
The U.S. Department of Agriculture’s (USDA) Animal and Plant Health Inspection Service (APHIS) announced on September 29, 2025,…
US Government to Scrutinize Farm Input Suppliers on Cost Surge
US Agriculture Secretary Brooke Rollins said the US will investigate suppliers of crop inputs such as seeds and…
Engineered prime editors with minimal genomic errors
Mammalian cell culture All mammalian cell cultures were maintained in a 37 °C incubator at 5% CO2. HEK293T human…
Gilgo Beach serial killer case a key test in use of advanced DNA techniques in criminal trials | National News
RIVERHEAD, N.Y. (AP) — When Maureen Brainard-Barnes’ skeletal remains were found hidden in the roadside scrub near Long…
Scientists ‘Hack’ Fruit Fly Romance By Transferring Vomit-Based Courtship Between Species
Drosophila subobscura males regurgitate food and offer it as a gift to females during courtship. (Credit: Tanaka et…