A Bayesian framework for longitudinal EHR and genetic discovery
Model We recapitulated the formulation of the model and provide a full account of model assumptions and implementation…
Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions
Lewis, A. C. F. et al. Managing differential performance of polygenic risk scores across groups: real-world experience of…
Cell-type-resolved genetic variation shapes inflammatory bowel disease risk
Patient recruitment and single-cell sequencing This study was approved by the National Health Service (NHS) Research Ethics Committee…
Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, LabEx DISTALZ—U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies…
Mechanism of age-related accumulation of mtDNA mutations in human blood
CohortsUK Biobank The UKB is a prospective cohort of approximately 500,000 individuals from the UK aged 40–70 years…
Genetic analysis of circulating metabolic traits in 619,372 individuals
Suzuki, K. et al. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature 627, 347–357 (2024). Article …
Genetic association and machine learning improve the prediction of type 1 diabetes risk
Ethics statement The use of human genetic data in this study was approved by the University of California,…
Telomere-to-telomere genome assemblies and population resequencing of diploid and allotetraploid peanut varieties
Assembly and annotation of six representative peanut genomes To determine the genome structure and genetic diversity of A.…
EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk
Study participants Participants from southern China were enrolled through two independent recruitments (sample sets 1 and 2). Participants…
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting
Fejzo, M. S. et al. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat. Rev. Dis. Primers 5,…
Genetic predictors of GLP1 receptor agonist weight loss and side effects
Overview of study recruitment Participants in this study were recruited from the customer base of 23andMe. Participants provided…
The DNA virome varies with human genes and environments
Ethics This research complies with all relevant ethical regulations. The study protocol (NHSR-8429) was determined to be not…