Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover
Goldstein, J. L. & Brown, M. S. A century of cholesterol and coronaries: from plaques to genes to…
A mechanism for adaptive genome regulation in cancer
Llinás, R. R. The contribution of Santiago Ramón y Cajal to functional neuroscience. Nat. Rev. Neurosci. 4, 77–80…
Ageing promotes metastasis via activation of the integrated stress response
Mice and in vivo studies KrasLSL-G12D/+Trp53flox/flox mice (designated as KP)60 were maintained on a mixed C57BL/6-129/Sv genetic background.…
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture
Human tissue collection Human tissue was acquired with written, informed consent under a National Institutes of Health Institutional…
Anti-progestin therapy targets hallmarks of breast cancer risk
The BC-APPS1 study The BC-APPS1 was a single-arm, single-centre phase II study registered under the name ‘a pilot…
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons
Isolation of nuclei from post-mortem brain tissue Batch 1 nuclei (BA10 region, frozen tissue) were isolated according to…