Memory stays strong in old age when this brain enzyme is active
Screening of mouse hippocampus cells (pictured) identified an enzyme whose production rose with age. Credit: Talley Lambert/Science Photo…
Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more
A detailed brain map describes gene activity in neurons (artist’s illustration) as well as immune and vascular cells…
Map of brain ‘microproteins’ could offer new clues to Alzheimer’s disease
Mapping microproteins in the brain might help to understand, and treat, Alzheimer’s disease.Credit: Zephyr/SPL More than 1,000 previously…
Cell-type signatures of Alzheimer’s disease shared across population groups
Study participants, ethics and clinicopathological characterization All brain tissue was obtained from participants in the Religious Order Study…
Gut Bacteria May Predict Parkinson’s Before Symptoms Appear
Summary: The fastest-growing neurodegenerative disease in the world may soon be detectable through a simple fecal sample. Researchers…
Cell-type-targeted mitochondrial transplantation rescues cell degeneration
Animals Animal experiments were performed following standard ethical guidelines (European Communities Guidelines on the Care and Use of…
AI Links Brain Rhythms to Physical “Wiring” Across Lifespan
Summary: For the first time, a multinational research team has mapped how the brain’s electrical activity evolves from…
These brain cells clear proteins that contribute to Alzheimer’s
Credit: Zephyr/Science Photo Library A group of specialized cells play a crucial part in clearing toxic proteins from…
Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia
Knopman, D. S. et al. Alzheimer disease. Nat. Rev. Dis. Primers 7, 33 (2021). Article PubMed PubMed Central …
How the brain protects itself from Alzheimer’s disease: study
High levels of calcium are toxic to cells and contribute to loss of neurons in Alzheimer’s disease. A…
‘Giant step forward’ for Huntington’s — the scientist behind the first gene therapy
On a video call in early September, Sarah Tabrizi first saw the data that she and other researchers…
Huntington’s disease treated for first time using gene therapy
A brain scan of a person with Huntington’s disease, which causes a loss of brain volume as neurons…