The expanding landscape of GLP-1 medicines
Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L. & Habener, J. F. Glucagon-like peptide I stimulates…
Culture is critical in driving orangutan diet development past individual potentials
Ethics statement Approval for data collection protocols at Suaq was provided by the Indonesian State Ministry for Research…
Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex
Ethics approval and consent to participate All methods were performed in accordance with the relevant guidelines and regulations.…
Entering the era of precision medicine to treat amyotrophic lateral sclerosis | Molecular Neurodegeneration
Goutman SA, Hardiman O, Al-Chalabi A, Chió A, Savelieff MG, Kiernan MC, Feldman EL. Emerging insights into the…
Genetic testing of common and rare variants in dementia patients from a memory clinic | Alzheimer’s Research & Therapy
2023 Alzheimer’s disease facts and figures. Alzheimers Dement 19, 1598–1695 (2023). Campion D, et al. Early-onset autosomal dominant…
Genetic and molecular landscape of comorbidities in people living with HIV
Participants from the 2000HIV study The 2000HIV study is a prospective multicentric observational longitudinal cohort of virally suppressed…
NLRP3 inflammasome and hearing loss: from mechanisms to therapies | Journal of Neuroinflammation
Sensorineural hearing loss (SNHL) affects approximately 1.5 billion people globally. Approximately 430 million of these patients require rehabilitation…
A centenarian single nucleotide polymorphism in collagen gene COL25A1 promotes longevity in C. elegans
Introduction of centenarian COL25A1 SNP in C. elegans ortholog col-99 In 2001, Puca and colleagues performed a linkage…
A genetic common factor underlying self-reported math ability and highest math class taken
Spearman C. The Abilities of Man: Their Nature and Measurement. New York: Macmillan; 1927. Google Scholar Jensen AR.…
Genetic nurture effects in depressive and anxiety disorders and symptoms, and in related traits
Polderman TJC, Benyamin B, De Leeuw CA, Sullivan PF, Van Bochoven A, Visscher PM, et al. Meta-analysis of…
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program
Enrollment rates Between 28 September 2023 and 10 June 2024 (~8.5 months), a total of 2,125 newborns were enrolled.…
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
Animals All mice were maintained according to the National Institutes of Health guidelines and all procedures used in…