Anti-progestin therapy targets hallmarks of breast cancer risk
The BC-APPS1 study The BC-APPS1 was a single-arm, single-centre phase II study registered under the name ‘a pilot…
Is heart disease preventable? How to reduce your risk, according to cardiologists
Heart disease continues to stand as the No. 1 cause of death in the United States. Coronary heart…
Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study
Ethics statement This trial has been registered at ClinicalTrials.gov (NCT04226911), was approved by national ethical committees (protocols and…
A longitudinal study examining determinants of essential health services during the COVID-19 pandemic in regional referral hospitals across Uganda
This study supported one of our three hypotheses: the stringency index reduced access to hospital services across the…
Development and internal validation of an AI-based emergency triage model for predicting critical outcomes in emergency department
This study demonstrates the potential of machine learning models to predict ICU admission from the ED more accurately…
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury
Reagents Chemicals used for cell death assays were dissolved in DMSO. 17β-oestradiol, testosterone and 2-hydroxyoestradiol were dissolved in…
Countrywide natural experiment links built environment to physical activity
Study design We conducted a countrywide, prospective, longitudinal physical activity study of US residents that evaluated their physical…
In vitro evidence of bubble-induced acoustic softening and Sanal flow choking in cardiovascular decompression
This pilot in vitro study explored how decompression-induced microbubble nucleation and acoustic softening contribute to flow instability and…
System dynamics modeling and simulation of exercise-based health promotion in the context of population aging
Simulation mode parameter setting Based on the social support theory, this study sets up five modes (Table 3) for…
Genetic insights into causal effects of lipids and lipid-modifying targets on calcific aortic valve stenosis: a Mendelian randomized study
Genetic variant selection After clumping, we identified 374 SNPs for TC, 415 for HDL-C, 313 for LDL-C and…
Trends in fetal autopsy and placental histopathology following stillbirth, United States, 2014–2023
Stillbirth affects approximately 1 in 175 births in the United States, totaling approximately 21,000 births each year [1].…
Positive association between Internet use and mental health among adults aged ≥50 years in 23 countries
Global Health Data Exchange (GHDx) (Institute of Health Metrics and Evaluation, accessed 1 November 2023); https://vizhub.healthdata.org/gbd-results Mental Health…