Artificial intelligence-enabled clinical phenotyping of human brown fat
Study design and participants This retrospective case–control study followed institutional guidelines and was approved by the Institutional Review…
Safety and security of large language models in healthcare
Gommers, J. et al. Interval cancer, sensitivity, and specificity comparing AI-supported mammography screening with standard double reading without…
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
An ECG biomarker for sudden cardiac death discovered with deep learning
Study cohort and outcomes: Sweden We obtained all 441,614 ECGs done from 2010 to 2016 in Region Halland,…
Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial
Study design This study is a secondary analysis of a randomized, placebo-controlled trial. The trial is registered with…
Towards autonomous medical artificial intelligence agents
MIMIC-IV datasetDataset description We develop a benchmark of 574 patients derived from the MIMIC-IV database which is a…
Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup
Sample acquisition and ethics approval The University of Pennsylvania institutional review board (IRB) approved the collection of human…
AI framework for multidisease detection via retinal imaging
Study population For the model training, we used CFPs from the UKB and three hospital-based centers in China…
Multicentre gene therapy for OTOF-related deafness followed up to 2.5 years
Yasunaga, S. et al. A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form…
Engineered immunosuppressive dendritic cells protect against cardiac remodelling
Conrad, N. et al. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million…
Childhood ADHD Tied to Higher Risk of Physical Health Problems by Midlife
Credit: SIphotography/Getty Images People who show attention-deficit/hyperactivity disorder (ADHD) traits in childhood are more likely to experience physical…