Divergent genomic evolution in astrocytomas and oligodendrogliomas
DNA sequencing WGS and WXS data were newly generated for the MD Anderson Cancer Center, Duke University Hospital,…
Modular in vivo antibody–ADC click to reverse drug resistance in tumours
Ethical compliance Animal studies were performed at the Washington University School of Medicine in compliance with institutional guidelines…
Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC
Kow, A. W. C. Hepatic metastasis from colorectal cancer. J. Gastrointest. Oncol. 10, 1274–1298 (2019). Article PubMed PubMed…
Ecotypes of triple-negative breast cancer in response to chemotherapy
Study participant details from the ARTEMIS Trial The clinical trial protocol was reviewed and approved by The University…
Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers
Patients This study was approved by the University Medical Centre (UMC) Utrecht ethical committee, carried out in accordance…
Dominant clones leverage developmental epigenomic states to drive ependymoma
In utero electroporation All animal procedures in this study were performed with approval from the St. Jude Institutional…
Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA
Sample collection All enrolled patients were consented to an institutional biospecimen banking protocol and MSK-IMPACT testing42, and all…
Mechanical confinement governs phenotypic plasticity in melanoma
Zebrafish husbandry Stable transgenic zebrafish lines were kept at 28.5 °C in a dedicated aquatics facility with a 14 h…