According to a comprehensive review published in the journal Nutrients, that saturation matters because of how creatine functions. ATP (adenosine triphosphate) is the main source of energy used by your muscles, brain, and almost every cell. During intense activity, your ATP supply runs out quickly. Creatine helps by increasing the amount of phosphocreatine stored in your cells, which helps regenerate ATP faster – so you can train harder, think clearer, and recover faster, even under stress or sleep deprivation.