Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner
Ethics approval and consent to participate All cohorts involving human participants that were included in this research have…
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Adapting prime editing for mammalian histone mutagenesis Mouse canonical histone H3 is encoded by nine H3.1 and three…
Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling
Derivation of retinal endothelial cells from human induced pluripotent stem cells via the Norrin–Fz4 axis To obtain RECs…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
Evaluating the robustness and readiness of large frontier models in health AI applications
Singhal, K. et al. Large language models encode clinical knowledge. Nature 620, 172–180 (2023). Article CAS PubMed PubMed…
Breathing life into digital twins
Using data from nearly 1,000 EVLP procedures, the authors assembled a longitudinal dataset spanning biochemical concentrations, physiological measurements,…
The promise of adaptive health in the United Arab Emirates and beyond
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA Andrew P. Feinberg Department of Biomedical Engineering, Johns Hopkins…
Towards mRNA therapeutics 2.0 | Nature Reviews Drug Discovery
Kallen, K.-J. et al. A novel, disruptive vaccination technology: self-adjuvanted RNActive® vaccines. Hum. Vaccin. Immunother. 9, 2263–2276 (2013). Article …
MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
Study conduct The trial was conducted from 19 May 2022 to 2 March 2026 (data cutoff date) in…
AI-induced never-skilling in medical education
Bajwa, J., Munir, U., Nori, A. & Williams, B. Artificial intelligence in healthcare: transforming the practice of medicine.…
Fetal monitoring for high-risk pregnancies using a wearable ultrasound patch
Woodward, P. J., Kennedy, A. & Sohaey, R. Diagnostic Imaging: Obstetrics 4th edn (Elsevier, 2021). Hutter, D., Kingdom,…