Polderman TJC, Benyamin B, De Leeuw CA, Sullivan PF, Van Bochoven A, Visscher PM, et al. Meta-analysis of the heritability of human traits based on fifty years of twin studies. Nat Genet. 2015;47:702–9.
Kendler KS, Ohlsson H, Sundquist K, Sundquist J. Sources of parent-offspring resemblance for major depression in a National Swedish Extended Adoption study. JAMA Psychiatry. 2018;75:194–200.
Kong A, Thorleifsson G, Frigge ML, Vilhjalmsson BJ, Young AI, Thorgeirsson TE, et al. The nature of nurture: effects of parental genotypes. Science. 2018;359:424.
Wang B, Baldwin JR, Schoeler T, Cheesman R, Barkhuizen W, Dudbridge F, et al. Robust genetic nurture effects on education: a systematic review and meta-analysis based on 38,654 families across 8 cohorts. Am J Hum Genet. 2021;108:1780–91.
Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease study 2019. The Lancet. 2020;396:1204–22.
Yonkers KA, Bruce SE, Dyck IR, Keller MB. Chronicity, relapse, and illness—course of panic disorder, social phobia, and generalized anxiety disorder: findings in men and women from 8 years of follow-up. Depress Anxiety. 2003;17:173–9.
Morris TT, Davies NM, Hemani G, Smith GD. Population phenomena inflate genetic associations of complex social traits. Sci Adv. 2020;6:eaay0328.
Cheesman R, Eilertsen EM, Ahmadzadeh YI, Gjerde LC, Hannigan LJ, Havdahl A, et al. How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa). BMC Med. 2020;18:284.
Jami ES, Eilertsen EM, Hammerschlag AR, Qiao Z, Evans DM, Ystrøm E, et al. Maternal and paternal effects on offspring internalizing problems: Results from genetic and family‐based analyses. Am J Med Genet B Neuropsychiatr Genet. 2020;183:258–67.
Jami ES, Hammerschlag AR, Sallis HM, Qiao Z, Andreassen OA, Magnus PM, et al. Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood? Transl Psychiatry. 2023;13:94.
Tubbs JD, Sham PC. Preliminary evidence for genetic nurture in depression and neuroticism through polygenic scores. JAMA Psychiatry. 2023;80:832–41.
Howe LJ, Nivard MG, Morris TT, Hansen AF, Rasheed H, Cho Y, et al. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects. Nat Genet. 2022;54:581–92.
Trindade Pons V, Claringbould A, Kamphuis P, Oldehinkel AJ, van Loo HM. Using parent-offspring pairs and trios to estimate indirect genetic effects in education. Genet Epidemiol. 2024;48:190–9.
Sijtsma A, Rienks J, van der Harst P, Navis G, Rosmalen JGM, Dotinga A. Cohort profile update: lifelines, a three-generation cohort study and biobank. Int J Epidemiol. 2022;51:e295–302.
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl 20):22–33.
Fedko IO, Hottenga JJ, Helmer Q, Mbarek H, Huider F, Amin N, et al. Measurement and genetic architecture of lifetime depression in the Netherlands as assessed by LIDAS (Lifetime Depression Assessment Self-report). Psychol Med. 2021;51:1345–54.
Costa PT, McCrae RR. Neo personality inventory-revised (NEO PI-R). FL: Psychological Assessment Resources Odessa; 1992.
Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol. 1988;54:1063–70.
Hofmeister RJ, Ribeiro DM, Rubinacci S, Delaneau O. Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK Biobank. Nat Genet. 2023;55:1243–9.
Howard DM, Adams MJ, Clarke TK, Hafferty JD, Gibson J, Shirali M, et al. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci. 2019;22:343–52.
Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, et al. Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nat Genet. 2020;52:437–47.
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 2018;50:668–81.
Privé F, Arbel J, Vilhjálmsson BJ. LDpred2: better, faster, stronger. Bioinformatics. 2021;36:5424–31.
Privé F, Albiñana C, Arbel J, Pasaniuc B, Vilhjálmsson BJ. Inferring disease architecture and predictive ability with LDpred2-auto. Am J Hum Genet. 2023;110:2042–55.
R Core Team. R: a language and environment for statistical computing. [Internet]. Vienna, Austria: Foundation for Statistical Computing; 2022. Available from: https://www.R-project.org/.
Rizopoulos D. GLMMadaptive: generalized linear mixed models using adaptive Gaussian quadrature [Internet]. Version 0.9-7. [place unknown]: GitHub; 2025 [cited 2025 Sep 16]. Available from: https://drizopoulos.github.io/GLMMadaptive/
Bates D, Mächler M, Bolker B, Walker S. Fitting Linear Mixed-Effects Models Using lme4. Journal of Statistical Software. 2015;67:1–48.
Kuznetsova A, Brockhoff PB, Christensen RHB. lmerTest package: tests in linear mixed effects models. J Stat Softw. 2017;82:1–26.
Torvik FA, Eilertsen EM, Hannigan LJ, Cheesman R, Howe LJ, Magnus P, et al. Modeling assortative mating and genetic similarities between partners, siblings, and in-laws. Nat Commun. 2022;13:1108.
Naragon-Gainey K, Watson D. What lies beyond neuroticism? an examination of the unique contributions of social-cognitive vulnerabilities to internalizing disorders. Assessment. 2018;25:143–58.
Hannigan LJ, Walaker N, Waszczuk MA, McAdams TA, Eley TC. Aetiological influences on stability and change in emotional and behavioural problems across development: a systematic review. Psychopathol Rev. 2017;4:52–108.
Shakeshaft A, Martin J, Dennison CA, Riglin L, Lewis CM, O’Donovan MC, et al. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Mol Psychiatry. 2024;29:238–46.
Jami ES, Hammerschlag AR, Bartels M, Middeldorp CM. Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature. Transl Psychiatry. 2021;11:197.
Silberg JL, Maes H, Eaves LJ. Genetic and environmental influences on the transmission of parental depression to children’s depression and conduct disturbance: an extended Children of Twins study. J Child Psychol Psychiatry. 2010;51:734–44.
Singh AL, D’Onofrio BM, Slutske WS, Turkheimer E, Emery RE, Harden KP, et al. Parental depression and offspring psychopathology: a Children of Twins study. Psychol Med. 2011;41:1385–95.
Elam K, Lemery-Chalfant K, Chassin L. A gene-environment cascade theoretical framework of developmental psychopathology. J Psychopathol Clin Sci. 2023;132:287–96.
Bjørndal LD, Eilertsen EM, Ayorech Z, Cheesman R, Ahmadzadeh YI, Baldwin JR, et al. Disentangling direct and indirect genetic effects from partners and offspring on maternal depression using trio-GCTA. Nat Ment Health. 2024;2:417–25.
Ten Have M, Tuithof M, Van Dorsselaer S, Schouten F, Luik AI, De Graaf R. Prevalence and trends of common mental disorders from 2007–2009 to 2019–2022: results from the Netherlands Mental Health Survey and Incidence Studies (NEMESIS), including comparison of prevalence rates before vs. during the COVID‐19 pandemic. World Psychiatry. 2023;22:275–85.
van Loo HM, Beijers L, Wieling M, de Jong TR, Schoevers RA, Kendler KS. Prevalence of internalizing disorders, symptoms, and traits across age using advanced nonlinear models. Psychol Med. 2023;53:78–87.
Martin J, Wray M, Agha SS, Lewis KJS, Anney RJL, O’Donovan MC, et al. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biol Psychiatry. 2023;93:37–44.
Adams MJ, Lewis CM, McIntosh AM Genome-wide study of major depression in 685,808 diverse individuals identifies 697 independent associations, infers causal neuronal subtypes and biological targets for novel pharmacotherapies. medRxiv:2024.04.29.24306535. 2024.
Doherty JL, Owen MJ. Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. Genome Med. 2014;6:29.
Wang R, Snieder H, Hartman CA. Familial co-aggregation and shared heritability between depression, anxiety, obesity and substance use. Transl Psychiatry. 2022;12:108.
Eilertsen EM, Cheesman R, Ayorech Z, Røysamb E, Pingault JB, Njølstad PR, et al. On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families. J Child Psychol Psychiatry. 2022;63:1186–95.
Saunders GRB, Liu M, Vrieze S, McGue M, Iacono WG. Mechanisms of parent-child transmission of tobacco and alcohol use with polygenic risk scores: evidence for a genetic nurture effect. Dev Psychol. 2021;57:796–804.
Thomas NS, Salvatore JE, Kuo SIC, Aliev F, McCutcheon VV, Meyers JM, et al. Genetic nurture effects for alcohol use disorder. Mol Psychiatry. 2023;28:759–66.
Vidal SI, Vandeleur C, Rothen S, Gholam-Rezaee M, Castelao E, Halfon O, et al. Risk of mental disorders in children of parents with alcohol or heroin dependence: a Controlled High-Risk study. Eur Addict Res. 2012;18:253–64.
Bountress K, Chassin L. Risk for behavior problems in children of parents with substance use disorders. Am J Orthopsychiatry. 2015;85:275–86.
Hill SY, Tessner KD, McDermott MD. Psychopathology in offspring from families of alcohol dependent female probands: a Prospective study. J Psychiatr Res. 2011;45:285–94.
Hussong AM, Flora DB, Curran PJ, Chassin LA, Zucker RA. Defining risk heterogeneity for internalizing symptoms among children of alcoholic parents. Dev Psychopathol. 2008;20:165–93.