Genetic association and machine learning improve the prediction of type 1 diabetes risk
Ethics statement The use of human genetic data in this study was approved by the University of California,…
Insights into human adaptation from ancient DNA
Dobzhansky, T. Nothing in biology makes sense except in the light of evolution. Am. Biol. Teach. 35, 125–129…
AI framework for multidisease detection via retinal imaging
Study population For the model training, we used CFPs from the UKB and three hospital-based centers in China…
Telomere-to-telomere genome assemblies and population resequencing of diploid and allotetraploid peanut varieties
Assembly and annotation of six representative peanut genomes To determine the genome structure and genetic diversity of A.…
Who owns my health data?
In Europe, nations are feeling pressure to keep the continent competitive in AI while staying inside strict privacy…
Genomic approaches for understanding the evolution of the human brain
Nurk, S. et al. The complete sequence of a human genome. Science 376, 44–53 (2022). Article PubMed PubMed…
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting
Fejzo, M. S. et al. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat. Rev. Dis. Primers 5,…
Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion
Furlong, E. E. M. & Levine, M. Developmental enhancers and chromosome topology. Science 361, 1341–1345 (2018). Article CAS …
De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion
Vermunt, M. W., Zhang, D. & Blobel, G. A. The interdependence of gene-regulatory elements and the 3D genome.…
Biallelic variants in RNU2-2 cause the most prevalent known recessive neurodevelopmental disorder
Genetic association analysis We identified the recessive form of RNU2-2 syndrome through a joint statistical analysis of the…
Single-cell spatial transcriptomic analysis of human skin anatomy
A single-cell spatial MERFISH atlas of normal human skin To map the cellular and spatial diversity of human…
Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial
Wu, Z., Zhang, W., Qu, J. & Liu, G. H. Emerging epigenetic insights into aging mechanisms and interventions.…