AI-powered blood test detects liver cancer across distinct populations
Researchers at the Johns Hopkins Kimmel Cancer Center validated an artificial intelligence (AI)-powered blood test that accurately detected liver cancer…
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764…
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Adapting prime editing for mammalian histone mutagenesis Mouse canonical histone H3 is encoded by nine H3.1 and three…
A Surprising Discovery Challenges What Scientists Thought DNA Methylation Was For
A study of sea anemones uncovers an ancient role for DNA methylation and shows that certain epigenetic changes…
World-first: therapy to make cells young again given to a person
Scientists are attempting to rejuvenate cells in the optic nerve (nerve fibres in red), which channels information from…
Scientists find hundreds of inherited DNA patterns that defy classic Mendelian genetics
For more than a century, heredity has been framed through the tidy logic of Mendel’s pea plants: traits…
New Research Shows Vitamin B12 May Hold the Key to Healthy Aging
A new Cornell study suggests vitamin B12 plays a far broader role in human biology than previously understood,…
Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion
Furlong, E. E. M. & Levine, M. Developmental enhancers and chromosome topology. Science 361, 1341–1345 (2018). Article CAS …
De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion
Vermunt, M. W., Zhang, D. & Blobel, G. A. The interdependence of gene-regulatory elements and the 3D genome.…
New Research Links Daily Multivitamins to Slower Biological Aging
In a randomized clinical trial of older adults, researchers found that taking multivitamins for two years modestly slowed…
Daily multivitamin slows signs of biological ageing
Taking multivitamins daily was associated with changes in epigenetic ageing ‘clocks’.Credit: Halfpoint Images/Getty Taking a multivitamin every day…
This compound enhances long-term memory of mice — but only in females
Mice were given acetate and then performed tasks that tested their memory.Credit: fergregory/iStock via Getty A common metabolic…