Cohesin prevents local mixing of condensed euchromatic domains in living human cells
All experiments complied with relevant ethical regulations. This study used established human cell lines and involved no human…
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764…
Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions
Lewis, A. C. F. et al. Managing differential performance of polygenic risk scores across groups: real-world experience of…
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Adapting prime editing for mammalian histone mutagenesis Mouse canonical histone H3 is encoded by nine H3.1 and three…
Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, LabEx DISTALZ—U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies…
Scientists identify hundreds of ancient genes associated with human diseases
When a child develops kidney failure or a rare bone disorder, the cause can seem painfully immediate. It…
Accurate, scalable and cross-platform cell identification for high-resolution spatial transcriptomics
Stahl, P. L. et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science…
Non-Mendelian inheritance of DNA methylation patterns in mice
Integrated genetic and epigenetic analysis of the intergenerational inheritance of DNA methylation patterns We designed a combined genetic…
Genetic association and machine learning improve the prediction of type 1 diabetes risk
Ethics statement The use of human genetic data in this study was approved by the University of California,…
Insights into human adaptation from ancient DNA
Dobzhansky, T. Nothing in biology makes sense except in the light of evolution. Am. Biol. Teach. 35, 125–129…
Telomere-to-telomere genome assemblies and population resequencing of diploid and allotetraploid peanut varieties
Assembly and annotation of six representative peanut genomes To determine the genome structure and genetic diversity of A.…
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting
Fejzo, M. S. et al. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat. Rev. Dis. Primers 5,…