Gene Function - United Kingdom News Beep

Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis

July 30, 2026

Mice Mice were of C57BL/6 background. The Muc2KO line used was described by Velcich et al.16. Mice containing…

Translating genomic data into healthcare practice with the Singapore National Precision Medicine program

July 29, 2026

Precision Health Research, Singapore (PRECISE), Singapore, Singapore Shih Wee Seow, Clement Qiwen Sin, Denise Xin Yi Chua, Emily Shu Fang Lau, Gloria…

HHealth

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry

July 22, 2026

Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764…

HHealth

Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders

July 21, 2026

Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim,…

HHealth

A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner

July 9, 2026

Ethics approval and consent to participate All cohorts involving human participants that were included in this research have…

SScience

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing

July 8, 2026

Adapting prime editing for mammalian histone mutagenesis Mouse canonical histone H3 is encoded by nine H3.1 and three…

HHealthcare

The promise of adaptive health in the United Arab Emirates and beyond

June 5, 2026

Department of Medicine, Johns Hopkins University, Baltimore, MD, USA Andrew P. Feinberg Department of Biomedical Engineering, Johns Hopkins…

HHealth

Age distinguishes selection from causation in cancer genomes

May 7, 2026

Defining the carcinogenic effect of mutations We defined the carcinogenic effect of a mutation by its influence on…

HHealth

Genetic association and machine learning improve the prediction of type 1 diabetes risk

May 1, 2026

Ethics statement The use of human genetic data in this study was approved by the University of California,…

HHealth

Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting

April 15, 2026

Fejzo, M. S. et al. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat. Rev. Dis. Primers 5,…

SScience

De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion

April 14, 2026

Vermunt, M. W., Zhang, D. & Blobel, G. A. The interdependence of gene-regulatory elements and the 3D genome.…

HHealth

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis

April 2, 2026

Building a harmonized ALS exome dataset for rare variant analysis To identify rare coding variants involved in ALS,…