Representations of the intrinsic value of information in mouse orbitofrontal cortex
Subjects All experimental and surgical protocols were performed in accordance with the guide of Care and Use of…
Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis
Mice Mice were of C57BL/6 background. The Muc2KO line used was described by Velcich et al.16. Mice containing…
Translating genomic data into healthcare practice with the Singapore National Precision Medicine program
Precision Health Research, Singapore (PRECISE), Singapore, Singapore Shih Wee Seow, Clement Qiwen Sin, Denise Xin Yi Chua, Emily Shu Fang Lau, Gloria…
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764…
Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders
Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim,…
A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner
Ethics approval and consent to participate All cohorts involving human participants that were included in this research have…
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Adapting prime editing for mammalian histone mutagenesis Mouse canonical histone H3 is encoded by nine H3.1 and three…
The promise of adaptive health in the United Arab Emirates and beyond
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA Andrew P. Feinberg Department of Biomedical Engineering, Johns Hopkins…
Age distinguishes selection from causation in cancer genomes
Defining the carcinogenic effect of mutations We defined the carcinogenic effect of a mutation by its influence on…
Genetic association and machine learning improve the prediction of type 1 diabetes risk
Ethics statement The use of human genetic data in this study was approved by the University of California,…
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting
Fejzo, M. S. et al. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat. Rev. Dis. Primers 5,…
De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion
Vermunt, M. W., Zhang, D. & Blobel, G. A. The interdependence of gene-regulatory elements and the 3D genome.…